Angelman+Syndrome

 **__Angelman Syndrome:__** By: K & B

__Angelman Syndrome__


 * Type of Genetic disorder**: This disorder is inherited when a child gets both chromosomes 15 from the father. Condition is called paternal uniparental disomy(UPD) or can be caused by deletion in the maternal chromosome. Another way that Angelman Sydrome can occur is mutation, which affects a control region, called the Imprinting Center(UBE3A gene). Random genetic events can also occur while in early reproduction stages or fetal develpment.

Chromosome 15 [|www.ipwso.org/images/chromosome_normal_delete.gif] www.sheldonhickey.com/ images/Maggie%20smile.jpg
 * Symptoms/Effects:** The symptoms are a stiff, unstable jerky gait, little to no speech skills, hand flapping movements, sunny dispostion/ very happy, hyperactive behavior, developmental delay, small head, and possibly mental retardation.
 * Diagnosis:** This syndrome is identified using a combination of clinical techniques and molecular genetic testing. 78% of individuals who have Angelman Syndrome have a deletion, uniparental disomy, or an imprinting defect, a small group have translocation or inversion (1%). 11%, have mutations and the problem with the last 10% who have the physical traits are unknown.


 * Prognosis:** Good chance of survival, mental delay, speech abnormalities, and a awkward gait. Patients with AS can improve their symptoms with therapy.


 * Treatment:** For physical problems(gait and balance problems), physical therapy and adaptive devices are used. Speech therapy for language problems and for epilepsy(neurological disorder that causes seizures), the patients are prescibed anticonvulsant medications.

Adaptive device: Sensor belt www.therapybelt.com/.../ therapy-belt-adults.jpg
 * Statistics:** It was found among all racial groups, and 1 per 12,000 to 20,000(or 0.01%) people are affected by Angelman syndrome.

__What parents have learned from their children with AS__
 * Fun Facts:**


 * An angels voice is louder then 200 people in a crowded restaurant.
 * You should not throw a ball when a ceiling fan is on.
 * A king-sized water bed has enough water to fill a 200 square foot house 4 inches deep.
 * When dialed randomly over a period of time numbers on a phone dial will combine in such a way that a three hour phone call to Scandinavia will appear on your phone bill.
 * VCRs do not eject peanut butter and jelly sandwiches.
 * Legos will pass through an Angel’s digestive track.
 * When you hear the toilet flush and an angel laugh, it is already too late.

Sources: [] [] [] __ [|http://www,wrongdiagnosis.com] __ []


 * Comments**

You guys did a good job, I like the baby picture. By the way, you should delete "By Kevin Ohhhhh and Brian Z'. (Cri-Du-Chat, LN) I like the fun facts, but wiki spaces says you mispelled legos, i can't believe it doesn't know the word- GC Tourettes This is really good. I especially like the fun facts, theyre really funny. (HG-Huntington's)