Hemophilia



**Hemophila **
**Hemophilia is a Genetic Disorder ** Hemohilia is a hereditary genetic disorder that stops the bodies ability to stop bleeding. Hemophilia is a sex-linked recessive trait. 70% of people get Hemophilia because they inherit it but the other 30% get it due to genetic mutation. Hemophilia is either inherited, your born with it, or aquired, which is when you develope it over time.

This genetic disorder prevents the blood from having the clotting factors needed to stop bleeding. When a blood vessel is injured, a temporary scab does form, but the missing clotting factors can't from a permanent scab so the wound can heal. So a person who is diagnosed with hemophilia, doesn't bleed more, but bleeds for a longer time. Some physical symptoms are large, deep bruises forming from internal bleeding. Longer periods of bleeding after surgery. Having nose bleeds for no reason is also sometimes a symptom.**Diagnosis ** The diagnosis of hemophilia is made by blood tests to determine if clotting factors are missing or at low levels, and which ones are causing the problem. Hemophilia can be treated with transfusions and plasma treatments there are still many complications that come with having the disease hemophilia.
 * Symptoms and Effects **

Chronic joint deformities can result from continued bleeding into the joints, but generally an orthopedic specialist can manage this. Some people may also develop antibodies to transfused factor VIII in the blood. This makes the transfusions ineffective and requires them to have replacement therapy much more often. People who have hemophilia are also very susceptible to having blood borne illness do to the many transfusions and in some cases of hemophilia people will die.  There is treatment available for people who have hemophilia. If a person has Hemophilia A, then they are missing the clotting factor 8. To treat this, they give a person a replacement of clotting factor 8. The replacement is a combination of blood with the clotting factor present, and clotting factor added to it. If a person has Hemophilia B, then they have low levels of of clotting factor 9. The same type of replacement of clotting factor treatment is used for Hemophilia B. Problems can develope with this treatment because ones body can develope anitbodies against the replacement clotting factor. If this happens, they can use different types of blood with the clotting factor.   There about 18,000 cases of hemophilia in the US 9/10 people have hemophilia A, if they are diagnosed with hemophilia. 7/10 who have hemophilia A, have the severe form of it, which means that they have less then 1% of clotting factor 8. There about 400 babies born with it each year Hemophilia occurs mostly in males
 * Prognosis **
 * [[image:protein_therapeautics_lg888_graphic.jpg width="192" height="156" align="left" caption="http://www.lentigen.com/images/protein_therapeautics_lg888_graphic.jpg"]]Treatment**
 * Statistics**

There arent that many famous cases in history, but one case does stand out. Queen Victoria of England, passed hemophilia to many of her descendants. Such as Alexandra, who was wife of Tsar Nicholas II of Russia. She passed it down to their son also. Since many royal families only marry to other royal families, there is interbreeding occuring. And since hemophilia is sex-linked recessive, many royal families have had hemophilia passed down. Making it a "Royal Genectic Disorder"
 * Other Information and Facts **

SOURCES: http://science.jrank.org/pages/3282/Hemophilia-How-hemophilia-inherited.html http://en.wikipedia.org/wiki/Haemophilia http://www.ikm.jmu.edu/Buttsjl/ISAT493/Hemophilia/hemophiliaprognosis.html []

You need 2 more pictures and finish Other Information and Facts. Otherwise, good information, good job (Cri-Du-Chat, LN) Where did Queen Victioria get the disease, its an interesting story and i would like to know more- GC tourettes
 * Comments

Good information, I liked the chart that you guys put up for your project, it gives a good look at the inheritance part of this disorder. You guys get an A-. - KO Angelman Syndrome**